Elucidating age and sex-dependent association between frontal EEG asymmetry and depression: An application of multiple imputation in functional regression.

ABSTRACT: Frontal power asymmetry (FA), a measure of brain function derived from electroencephalography, is a potential biomarker for major depressive disorder (MDD). Though FA is functional in nature, it is typically reduced to a scalar value prior to analysis, possibly obscuring its relationship with MDD and leading to a number of studies that have provided contradictory results. To overcome this issue, we sought to fit a functional regression model to characterize the association between FA and MDD status, adjusting for age, sex, cognitive ability, and handedness using data from a large clinical study that included both MDD and healthy control (HC) subjects. Since nearly 40% of the observations are missing data on either FA or cognitive ability, we propose an extension of multiple imputation (MI)

SUBMITTER: Ciarleglio A 

PROVIDER: S-EPMC8959477 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature