A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolates.

ABSTRACT: Placental malaria (PM) is a deadly syndrome most frequent and severe in first pregnancies. PM results from accumulation of Plasmodium falciparum-infected erythrocytes (IE) that express the surface antigen VAR2CSA and bind to chondroitin sulfate A (CSA) in the placenta. Women become PM-resistant over successive pregnancies as they develop anti-adhesion and anti-VAR2CSA antibodies, supporting VAR2CSA as the leading PM-vaccine candidate. However, the first VAR2CSA subunit vaccines failed to induce broadly neutralizing antibody and it is known that naturally acquired antibodies target both variant-specific and conserved epitopes. It is crucial to determine whether effective vaccines will require incorporation of many or only a single VAR2CSA variants. Here, IgG from multigravidae was se

SUBMITTER: Doritchamou JYA 

PROVIDER: S-EPMC8959597 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature