Lifestyle Modifies the Diabetes-Related Metabolic Risk, Conditional on Individual Genetic Differences.

ABSTRACT: Metabolic syndrome is a group of heritable metabolic traits that are highly associated with type 2 diabetes (T2DM). Classical interventions to T2DM include individual self-management of environmental risk factors, such as improving diet quality, increasing physical activity, and reducing smoking and alcohol consumption, which decreases the risk of developing metabolic syndrome. However, it is poorly understood how the phenotypes of diabetes-related metabolic traits change with respect to lifestyle modifications at the individual level. In the analysis, we used 12 diabetes-related metabolic traits and eight lifestyle covariates from the UK Biobank comprising 288,837 white British participants genotyped for 1,133,273 genome-wide single nucleotide polymorphisms. We found 16 GxE interactions.

SUBMITTER: Shin J 

PROVIDER: S-EPMC8959634 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature