DNA Methylation Associates With Clinical Courses of Atypical Meningiomas: A Matched Case-Control Study.

ABSTRACT:

Background

Accounting for 15-20% of all meningiomas, WHO grade II meningiomas represent an intermediate group regarding risk of tumor recurrence. However, even within this subgroup varying clinical courses are observed with potential occurrence of multiple recurrences. Recently, DNA methylation profiles showed their value for distinguishing biological behaviors in meningiomas. Therefore, aim of this study was to investigate DNA methylation profiles in WHO grade II meningiomas.

Methods

All patients that underwent resection of WHO grade II meningiomas between 1993 and 2015 were screened for a dismal course clinical course with ≥2 recurrences. These were matched to control cases with benign clinical courses without tumor recurrence. DNA methylation was assessed using the Infini

SUBMITTER: Millesi M 

PROVIDER: S-EPMC8959647 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature