A Stoichiometric Solvent-Free Protocol for Acetylation Reactions.

ABSTRACT: Considering the remarkable relevance of acetylated derivatives of phenols, alcohols, and aryl and alkyl thiols in different areas of biology, as well as in synthetic organic chemistry, a sustainable solvent-free approach to perform acetylation reactions is proposed here. Acetylation reactions are classically performed using excess of acetic anhydride (Ac₂O) in solvent-free conditions or by eventually working with stoichiometric amounts of Ac₂O in organic solvents; both methods require the addition of basic or acid catalysts to promote the esterification. Therefore, they usually lead to the generation of high amounts of wastes, which sensibly raise the E-factor of the process. With the aim to develop a more sustainable system, a solvent-free, stoichiometric acetylation

SUBMITTER: Valentini F 

PROVIDER: S-EPMC8959667 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature