Delivering Singlet Oxygen in Dark Condition With an Anthracene-Functionalized Semiconducting Compound for Enhanced Phototheranostics.

ABSTRACT: Photodynamic therapy (PDT) utilizes the photogeneration of reactive oxygen species (ROS) with high cytotoxicity to kill cancer cells, holding great promise for cancer treatment. Fractionated delivery of singlet oxygen (¹O₂) is a wise approach to relieving hypoxia, thus enhancing the therapeutic efficacy. In this article, an anthracene-functionalized semiconducting compound (DPPA) has been designed and synthesized. With irradiation, the compound is able to undergo efficient intersystem crossing (ISC) and non-radioactive decay for photodynamic/photothermal synergistic therapy. In addition, the anthracene module is able to capture and release ¹O₂ reversibly with or without irradiation. DPPA nanoparticles (NPs) obtained by nanoprecipitation with DSPE

SUBMITTER: Shen J 

PROVIDER: S-EPMC8959821 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature