Aquaporin-4 Polymorphisms Are Associated With Cognitive Performance in Parkinson's Disease.

ABSTRACT:

Objective

Aquaporin-4 (AQP4) facilitates a sleep-enhanced interstitial brain waste clearance system. This study was conducted to determine the clinical implication of AQP4 polymorphisms in Parkinson's disease (PD).

Methods

Three-hundred and eighty-two patients with PD and 180 healthy controls with a mean follow-up time of 66.1 months from the Parkinson's Progression Marker Initiative study were analyzed. We examined whether AQP4 SNPs were associated with an altered rate of motor or cognitive decline using linear mixed model and Cox regression. We then investigated whether AQP4 SNPs were associated with Aβ burden as measured by ¹⁸F Florbetapir standard uptake values. Furthermore, we examined if AQP4 SNPs moderated the association between

SUBMITTER: Fang Y 

PROVIDER: S-EPMC8959914 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature