Angiotensin System Autoantibodies Correlate With Routine Prognostic Indicators for COVID-19 Severity.

ABSTRACT:

Objective

We previously showed that angiotensin type-1 receptor and ACE2 autoantibodies (AT1-AA, ACE2-AA) are associated with COVID-19 severity. Our aim is to find correlations of these autoantibodies with routine biochemical parameters that allow an initial classification of patients.

Methods

In an initial cohort of 119 COVID-19 patients, serum AT1-AA and ACE2-AA concentrations were obtained within 24 h after diagnosis. In 50 patients with a complete set of routine biochemical parameters, clinical data and disease outcome information, a Random Forest algorithm was used to select prognostic indicators, and the Spearman coefficient was used to analyze correlations with AT1-AA, ACE2-AA.

Results

Hemoglobin, lactate dehydrogenase and procalcitonin were selected. A decreas

SUBMITTER: Labandeira CM 

PROVIDER: S-EPMC8959920 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature