Development and Validation of Prediction Models for Hypertensive Nephropathy, the PANDORA Study.

ABSTRACT:

Importance

Hypertension is a leading cause of end-stage renal disease (ESRD), but currently, those at risk are poorly identified.

Objective

To develop and validate a prediction model for the development of hypertensive nephropathy (HN).

Design setting and participants

Individual data of cohorts of hypertensive patients from Kailuan, China served to derive and validate a multivariable prediction model of HN from 12, 656 individuals enrolled from January 2006 to August 2007, with a median follow-up of 6.5 years. The developed model was subsequently tested in both derivation and external validation cohorts.

Variables

Demographics, physical examination, laboratory, and comorbidity variables.

Main outcomes and measures

Hypertensive nephropathy was defined as

SUBMITTER: Yang X 

PROVIDER: S-EPMC8960139 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature