Fatty acid binding protein 4 regulates pancreatic cancer cell proliferation via activation of nuclear factor E2-related factor 2.

ABSTRACT:

Background

Obesity and diabetes are associated with an increased incidence of pancreatic cancer. Fatty acid binding protein 4 (FABP4), noted to be higher in patients with severe obesity, is linked to the development and progression of several cancers, and its level in the circulation decreases after bariatric surgery.

Objective

In this paper, we evaluate the role of FABP4 in pancreatic cancer progression.

Setting

University Hospital and Laboratories, United States.

Methods and results

When Panc-1 (human) and Pan02 (mouse) pancreatic cancer cells were treated with FABP4 or the-single-point mutant FABP4 (R126Q, fatty acid binding site mutant), only FABP4 stimulated cellular proliferation. The transcriptional activity of nuclear factor E2-related factor 2 (NRF2) w

SUBMITTER: Wirth K 

PROVIDER: S-EPMC8960336 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature