High-sensitivity C-reactive protein and all-cause mortality in four diverse populations: The CRONICAS Cohort Study.

ABSTRACT:

Purpose

To assess the association between all-cause mortality and hs-CRP, based mainly on the cumulative burden approach.

Methods

Cohort study with adults ≥35 years from general population, using hs-CRP at two timepoints: at baseline and 30 months later to establish different exposures: change over time, cumulative, and weighted cumulative hs-CRP. The outcome was all-cause mortality assessed 7 years later. Cox models were generated to quantify the association.

Results

Data from 3,119 participants (mean age 55.6 years, and 51.2% females), were analyzed. During follow-up, 164 (5.6%) deaths occurred over 20,314.5 person-years, indicating an overall mortality rate of 8.1 per 1,000 person-years. In multivariable model, hs-CRP at baseline was associated with high risk of mo

SUBMITTER: Bernabe-Ortiz A 

PROVIDER: S-EPMC8960343 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature