Mechanisms of cellular and humoral immunity through the lens of VLP-based vaccines.

ABSTRACT:

Introduction

Vaccination can be effective defense against many infectious agents and the corresponding diseases. Discoveries elucidating the mechanisms of the immune system have given hopes to developing vaccines against diseases recalcitrant to current treatment/prevention strategies. One such finding is the ability of immunogenic biological nanoparticles to powerfully boost the immunogenicity of poorer antigens conjugated to them with virus-like particle (VLP)-based vaccines as a key example. VLPs take advantage of the well-defined molecular structures associated with sub-unit vaccines and the immunostimulatory nature of conjugate vaccines.

Areas covered

In this review, we will discuss how advances in understanding the immune system can inform VLP-based vaccine design and

SUBMITTER: McFall-Boegeman H 

PROVIDER: S-EPMC8960355 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature