Presence of H3K4me3 on Paternally Expressed Genes of the Paternal Genome From Sperm to Implantation.

ABSTRACT: Genomic imprinting, parent-of-origin-specific gene expression, is controlled by differential epigenetic status of the parental chromosomes. While DNA methylation and suppressive histone modifications established during gametogenesis suppress imprinted genes on the inactive allele, how and when the expressed allele gains its active status is not clear. In this study, we asked whether the active histone-3 lysine-4 trimethylation (H3K4me3) marks remain at paternally expressed genes (PEGs) in sperm and embryos before and after fertilization using published data. Here we show that mouse sperm had the active H3K4me3 at more than half of known PEGs, and these genes were present even after fertilization. Using reciprocal cross data, we identified 13 new transient PEGs during zygotic genome activat

SUBMITTER: Ishihara T 

PROVIDER: S-EPMC8960379 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature