Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks.

ABSTRACT: Activity in the healthy brain relies on a concerted interplay of excitation (E) and inhibition (I) via balanced synaptic communication between glutamatergic and GABAergic neurons. A growing number of studies imply that disruption of this E/I balance is a commonality in many brain disorders; however, obtaining mechanistic insight into these disruptions, with translational value for the patient, has typically been hampered by methodological limitations. Cadherin-13 (CDH13) has been associated with autism and attention-deficit/hyperactivity disorder. CDH13 localizes at inhibitory presynapses, specifically of parvalbumin (PV) and somatostatin (SST) expressing GABAergic neurons. However, the mechanism by which CDH13 regulates the function of inhibitory synapses in human neurons remains unknown.

SUBMITTER: Mossink B 

PROVIDER: S-EPMC8960401 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature