The Th1 cell regulatory circuitry is largely conserved between human and mouse.

ABSTRACT: Gene expression programs controlled by lineage-determining transcription factors are often conserved between species. However, infectious diseases have exerted profound evolutionary pressure, and therefore the genes regulated by immune-specific transcription factors might be expected to exhibit greater divergence. T-bet (Tbx21) is the immune-specific, lineage-specifying transcription factor for T helper type I (Th1) immunity, which is fundamental for the immune response to intracellular pathogens but also underlies inflammatory diseases. We compared T-bet genomic targets between mouse and human CD4⁺ T cells and correlated T-bet binding patterns with species-specific gene expression. Remarkably, we found that the majority of T-bet target genes are conserved between mouse and huma

SUBMITTER: Henderson S 

PROVIDER: S-EPMC8960437 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature