Characterization of a Mycobacterium smegmatis mutant lacking penicillin binding protein 1.

ABSTRACT: The ponA gene of Mycobacterium smegmatis encodes a 95-kDa penicillin binding protein, PBP1, that is similar to PBP1s of Mycobacterium tuberculosis and Mycobacterium leprae. Transposon disruption of ponA in M. smegmatis resulted in a PBP1-deficient mutant that was sensitive to beta-lactam antibiotics, was more permeable to glycine, and grew slowly in liquid culture.

SUBMITTER: Billman-Jacobe H 

PROVIDER: S-EPMC89605 | biostudies-literature | 1999 Dec

REPOSITORIES: biostudies-literature