A new concept for the production of ¹¹C-labelled radiotracers.

ABSTRACT:

Background

The GMP-compliant production of radiopharmaceuticals has been performed using disposable units (cassettes) with a dedicated synthesis module. To expand this "plug 'n' synthesize" principle to a broader scope of modules we developed a pressure controlled setup that offers an alternative to the usual stepper motor controlled rotary valves. The new concept was successfully applied to the synthesis of N-methyl-[¹¹C]choline, L-S-methyl-[¹¹C]methionine and [¹¹C]acetate.

Results

The target gas purification of cyclotron produced [¹¹C]CO₂ and subsequent conversion to [¹¹C]MeI was carried out on a TRACERlab Fx C Pro module. The labelling reactions were controlled with a TRACERlab Fx FE module. With the presen

SUBMITTER: Wenz J 

PROVIDER: S-EPMC8960519 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature