Mathematical modelling of oxygenation under veno-venous ECMO configuration using either a femoral or a bicaval drainage.

ABSTRACT:

Background

The bicaval drainage under veno-venous extracorporeal membrane oxygenation (VV ECMO) was compared in present experimental study to the inferior caval drainage in terms of systemic oxygenation.

Method

Two mathematical models were built to simulate the inferior vena cava-to-right atrium (IVC → RA) route and the bicaval drainage-to-right atrium return (IVC + SVC → RA) route using the following parameters: cardiac output (Q_C), IVC flow/Q_C ratio, venous oxygen saturation, extracorporeal pump flow (Q_EC), and pulmonary shunt (PULM-Shunt) to obtain pulmonary artery oxygen saturation (S_PAO₂) and systemic blood oxygen saturation (SaO₂).

Results

With the IVC → RA route, S_PAO₂ and S

SUBMITTER: Charbit J 

PROVIDER: S-EPMC8960524 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature