Association of Thiamine Use with Outcomes in Patients with Sepsis and Alcohol Use Disorder: An Analysis of the MIMIC-III Database.

ABSTRACT:

Introduction

The association between thiamine use and clinical outcomes among patients with sepsis and alcohol use disorder (AUD) is unclear.

Methods

In this retrospective cohort study of patients from Medical Information Mart for Intensive Care III (MIMIC-III, version 1.4), we evaluated the association of thiamine use with clinical outcomes in patients with AUD and sepsis. The primary outcome was 28-day survival, and secondary outcomes included ICU, in-hospital, and 90-day mortality, ICU and hospital length of stay, duration of vasopressor use, need and duration of continuous renal replacement therapy (CRRT), and dynamic changes for variables up to day 7 after ICU admission.

Results

A total of 944 patients with sepsis and AUD were included in this cohort [median age,

SUBMITTER: Hu C 

PROVIDER: S-EPMC8960538 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature