Trends in heart disease mortality among breast cancer survivors in the US, 1975-2017.

ABSTRACT:

Purpose

Heart disease is a significant concern among breast cancer survivors, in part due to cardiotoxic treatments including chemotherapy and radiotherapy. Long-term trends in heart disease mortality have not been well characterized. We examined heart disease mortality trends among US breast cancer survivors by treatment type.

Methods

We included first primary invasive breast cancer survivors diagnosed between 1975 and 2016 (aged 18-84; survived 12 + months; received initial chemotherapy, radiotherapy, or surgery) in the SEER-9 Database. Standardized mortality ratios (SMRs) and 10-year cumulative heart disease mortality estimates accounting for competing events were calculated by calendar year of diagnosis and initial treatment regimen. P_trends were assessed usin

SUBMITTER: Vo JB 

PROVIDER: S-EPMC8960573 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature