Identification of Epigenetically Modified Hub Genes and Altered Pathways Associated With Retinoblastoma.

ABSTRACT: Retinoblastoma (Rb) is the most common childhood malignancy initiated by biallelic mutation in RB1 gene and driven by various epigenetic events including DNA methylation and microRNA dysregulation. Hence, understanding the key genes that are critically modulated by epigenetic modifications in RB1 ^-/- cells is very important to identify prominent biomarkers and therapeutic targets of Rb. In this study, we for the first time have integrated various Rb microarray NCBI-GEO datasets including DNA Methylation (GSE57362), miRNA (GSE7072) and mRNA (GSE110811) to comprehensively investigate the epigenetic consequences of RB loss in retinoblastoma tumors and identify genes with the potential to serve as early diagnostic markers and therapeutic targets for Rb. I

SUBMITTER: Karmakar A 

PROVIDER: S-EPMC8960645 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature