Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice.

ABSTRACT:

Aims/hypothesis

Diabetic cardiomyopathy (DCM) is a serious and under-recognised complication of diabetes. The first sign is diastolic dysfunction, which progresses to heart failure. The pathophysiology of DCM is incompletely understood but microcirculatory changes are important. Endothelial glycocalyx (eGlx) plays multiple vital roles in the microcirculation, including in the regulation of vascular permeability, and is compromised in diabetes but has not previously been studied in the coronary microcirculation in diabetes. We hypothesised that eGlx damage in the coronary microcirculation contributes to increased microvascular permeability and hence to cardiac dysfunction.

Methods

We investigated eGlx damage and cardiomyopathy in mouse models of type 1 (streptozotocin-induced

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC8960650 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature