A Mathematical Model for Electrical Activity in Pig Atrial Tissue.

ABSTRACT: State of the art mathematical models are currently used to bridge the gap between basic research conducted in the laboratory and preclinical research conducted on large animals, which ultimately paves the way for clinical translation. In this regard, there is a great need for models that can be used alongside experiments for in-depth investigation and validation. One such experimental model is the porcine atrium, which is commonly used to study the mechanisms of onset and control of atrial fibrillation in the context of its surgical management. However, a mathematical model of pig atria is lacking. In this paper, we present the first ionically detailed mathematical model of porcine atrial electrophysiology, at body temperature. The model includes 12 ionic currents, 4 of which were designed

SUBMITTER: Peris-Yague V 

PROVIDER: S-EPMC8960738 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature