MicroRNAs in Serum Exosomes as Circulating Biomarkers for Postmenopausal Osteoporosis.

ABSTRACT: Postmenopausal osteoporosis (PMOP) is the most common skeletal disease in postmenopausal women and has become a global public health issue. Emerging evidence demonstrated the important relationship between microRNAs and PMOP. However, miRNAs have not yet been reported in PMOP. Hence, the present study aimed to investigate the differences in miRNA expression profiles in PMOP with fragility fractures to identify the key circulating miRNAs in serum exosomes and to validate these molecules as potential biomarkers. Postmenopausal women with osteoporotic fracture and normal bone mass were enrolled. Serum exosomes were isolated by traditional differential ultracentrifugation from participants. Isolated exosomes were identified by electron microscopy, western blotting and nanoparticle-tracking ana

SUBMITTER: Shi H 

PROVIDER: S-EPMC8960856 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature