Systematic review of wastewater surveillance of antimicrobial resistance in human populations.

ABSTRACT:

Objectives

We systematically reviewed studies using wastewater for AMR surveillance in human populations, to determine: (i) evidence of concordance between wastewater-human AMR prevalence estimates, and (ii) methodological approaches which optimised identifying such an association, and which could be recommended as standard. We used Lin's concordance correlation coefficient (CCC) to quantify concordance between AMR prevalence estimates in wastewater and human compartments (where CCC = 1 reflects perfect concordance), and logistic regression to identify study features (e.g. sampling methods) associated with high agreement studies (defined as >70% of within-study wastewater-human AMR prevalence comparisons within ±10%).

Results

Of 8,867 records and 441 full-text methods review

SUBMITTER: Chau KK 

PROVIDER: S-EPMC8960996 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature