Ventralis intermedius nucleus anatomical variability assessment by MRI structural connectivity.

ABSTRACT: The ventralis intermedius nucleus (Vim) is centrally placed in the dentato-thalamo-cortical pathway (DTCp) and is a key surgical target in the treatment of severe medically refractory tremor. It is not visible on conventional MRI sequences; consequently, stereotactic targeting currently relies on atlas-based coordinates. This fails to capture individual anatomical variability, which may lead to poor long-term clinical efficacy. Probabilistic tractography, combined with known anatomical connectivity, enables localisation of thalamic nuclei at an individual subject level. There are, however, a number of confounds associated with this technique that may influence results. Here we focused on an established method, using probabilistic tractography to reconstruct the DTCp, to identify the connec

SUBMITTER: Ferreira F 

PROVIDER: S-EPMC8960999 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature