Comparative efficacy and safety of vaccines to prevent seasonal influenza: A systematic review and network meta-analysis.

ABSTRACT:

Background

Influenza is one of the most common respiratory viral infections worldwide. Numerous vaccines are used to prevent influenza. Their selection should be informed by the best available evidence. We aimed to estimate the comparative efficacy and safety of seasonal influenza vaccines in children, adults and the elderly.

Methods

We conducted a systematic review and network meta-analysis (NMA). We searched the Cochrane Library Central Register of Controlled Trials, MEDLINE and EMBASE databases, and websites of regulatory agencies, through December 15th, 2020. We included placebo- or no vaccination-controlled, and head-to-head randomized clinical trials (RCTs). Pairs of reviewers independently screened the studies, abstracted the data, and appraised the risk of bias in ac

SUBMITTER: Minozzi S 

PROVIDER: S-EPMC8961170 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature