P2X7 receptor induces microglia polarization to the M1 phenotype in cancer-induced bone pain rat models.

ABSTRACT:

Background

The transition from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype presents a novel therapeutic strategy for chronic pain.

Objective

We investigated the role of microglia polarization in cancer-induced bone pain (CIBP), as well as the role of the P2X7 receptor in modulating M1 to M2 polarization.

Methods

Walker-256 breast cancer cells were administered into tibias of female rats to induce bone cancer-associated cancer.

Results

During bone cancer development, the P2X7 receptor and M1 microglia markers were upregulated. In contrast, inhibition of the P2X7 receptor by BBG, a blood-brain barrier-permeable P2X7R-specific antagonist, alleviated the pain and promoted microglia polarization toward the M2 phenotype, while suppressing the M1 p

SUBMITTER: Wu P 

PROVIDER: S-EPMC8961217 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature