Alterations in Cortical-Subcortical Metabolism in Temporal Lobe Epilepsy With Impaired Awareness Seizures.

ABSTRACT:

Objective

The features of cerebral metabolism associated with loss of consciousness in patients with temporal lobe epilepsy (TLE) have not been fully elucidated. We aim to investigate the alterations in cortical-subcortical metabolism in temporal lobe epilepsy with impaired awareness seizures (IAS).

Methods

Regional cerebral metabolism was measured using fluorine-18-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG PET) in patients with TLE-IAS and healthy controls. All patients had a comprehensive evaluation to confirm their seizure origin and lateralization. Videos of all seizures were viewed and rated by at least two epileptologists to identify the state of consciousness when a seizure occurred. By synthesizing the seizure history, semeiology, and video

SUBMITTER: Hou J 

PROVIDER: S-EPMC8961434 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature