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Comprehensive review on molnupiravir in COVID-19: a novel promising antiviral to combat the pandemic.

ABSTRACT: Despite the progress in the management of COVID-19, effective oral antiviral agents are still lacking. In the present review, the potential beneficial effects of molnupiravir in the management of COVID-19 are discussed. A literature search in Google Scholar, Scopus, PubMed and clinicaltrials.gov for the relevant articles regarding the pharmacokinetics, pharmacodynamics and clinical trials of molnupiravir in the management of COVID-19 is conducted. Most of the preclinical studies and available clinical trials showed a favorable short-term safety profile of molnupiravir; however, given its possible genotoxic effects, further trials are required to confirm the long-term efficacy and safety of molnupiravir in patients with COVID-19.

SUBMITTER: Khiali S

PROVIDER: S-EPMC8961474 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Comprehensive review on molnupiravir in COVID-19: a novel promising antiviral to combat the pandemic.

Khiali Sajad S Khani Elnaz E B Rouy Samineh S Entezari-Maleki Taher T

Future microbiology 20220224

Despite the progress in the management of COVID-19, effective oral antiviral agents are still lacking. In the present review, the potential beneficial effects of molnupiravir in the management of COVID-19 are discussed. A literature search in Google Scholar, Scopus, PubMed and clinicaltrials.gov for the relevant articles regarding the pharmacokinetics, pharmacodynamics and clinical trials of molnupiravir in the management of COVID-19 is conducted. Most of the preclinical studies and available cl ...[more]

PMID: 35199608

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| S-EPMC8704035 | biostudies-literature

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