Impact of Vimentin on Regulation of Cell Signaling and Matrix Remodeling.

ABSTRACT: Vimentin expression contributes to cellular mechanoprotection and is a widely recognized marker of fibroblasts and of epithelial-mesenchymal transition. But it is not understood how vimentin affects signaling that controls cell migration and extracellular matrix (ECM) remodeling. Recent data indicate that vimentin controls collagen deposition and ECM structure by regulating contractile force application to the ECM and through post-transcriptional regulation of ECM related genes. Binding of cells to the ECM promotes the association of vimentin with cytoplasmic domains of adhesion receptors such as integrins. After initial adhesion, cell-generated, myosin-dependent forces and signals that impact vimentin structure can affect cell migration. Post-translational modifications of vimentin determ

SUBMITTER: Ostrowska-Podhorodecka Z 

PROVIDER: S-EPMC8961691 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature