Trends in Pediatric Primary Immunodeficiency: Incidence, Utilization, Transplantation, and Mortality.

ABSTRACT:

Background

Primary immunodeficiency disorders (PIDDs) describe a myriad of diseases caused by inherited defects within the immune system. As the number of identified genetic defects associated with PIDDs increases, understanding the incidence and outcomes of PIDD patients becomes imperative.

Objective

To characterize the frequency of new diagnoses, patterns of health care utilization, rates of hematopoietic stem cell transplantation (HSCT), and mortality in pediatric patients with PIDDs.

Methods

A retrospective cohort analysis of the Pediatric Health Information System database from 2004 to 2018 for pediatric inpatients with an International Classification of Diseases, Ninth and 10th Revisions (ICD-9/ICD-10). code associated with PIDD.

Results

A total of 17,234

SUBMITTER: Eddens T 

PROVIDER: S-EPMC8961698 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature