Neuronal GHS-R Differentially Modulates Feeding Patterns under Normal and Obesogenic Conditions.

ABSTRACT: The orexigenic hormone ghrelin increases food intake and promotes obesity through its receptor, growth hormone secretagogue receptor (GHS-R). We previously reported two neuron-specific GHS-R knockout mouse lines, namely pan-neuronal deletion by Syn1-cre and hypothalamic deletion by AgRP-cre, exhibiting differential diet-dependent effects on body weight. GHS-R deficiency in neurons elicited less pronounced metabolic effects under regular diet (RD) than high fat diet (HFD). While there was no difference in total food intake of HFD in either mouse line, Syn1-cre; Ghsr^f/f mice showed much greater anti-obesity effect than that of AgRP-cre; Ghsr^f/f mice. Meal feeding pattern is known to have a major impact on energy homeostasis and obesity development. Here, w

SUBMITTER: Lee JH 

PROVIDER: S-EPMC8961776 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature