N6-Methyladenosine Regulator-Mediated Immue Patterns and Tumor Microenvironment Infiltration Characterization in Glioblastoma.

ABSTRACT:

Background

Epigenetic modifications, according to emerging evidence, perform a critical role for cellular immune response and tumorigenesis. Nonetheless, the role of N6-methyladenosine modification in shaping of the glioblastoma tumor microenvironment is unknown.

Methods

N6-methyladenosine(m6A) methylation patterns in GBM patients were evaluated via multiple omics analysis of 15 m6A regulators and systematically correlated with tumor immune features. For quantification of N6-methyladenosine methylation patterns of individual patients, GM-score was developed and correlated with clinical and immunological characteristics.

Results

Glioblastoma has two different m6A methylation patterns that are strongly associated with TME characteristics, tumor subtype, immunothe

SUBMITTER: Xiong W 

PROVIDER: S-EPMC8961865 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature