Nyssorhynchus darlingi genome-wide studies related to microgeographic dispersion and blood-seeking behavior.

ABSTRACT:

Background

In Brazil, malaria is concentrated in the Amazon Basin, where more than 99% of the annual cases are reported. The main goal of this study was to investigate the population structure and genetic association of the biting behavior of Nyssorhynchus (also known as Anopheles) darlingi, the major malaria vector in the Amazon region of Brazil, using low-coverage genomic sequencing data.

Methods

Samples were collected in the municipality of Mâncio Lima, Acre state, Brazil between 2016 and 2017. Different approaches using genotype imputation and no gene imputation for data treatment and low-coverage sequencing genotyping were performed. After the samples were genotyped, population stratification analysis was performed.

Results

Weak but statistically significant stra

SUBMITTER: Alvarez MVN 

PROVIDER: S-EPMC8961893 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature