Transcriptome-wide N6-methyladenine methylation in granulosa cells of women with decreased ovarian reserve.

ABSTRACT:

Background

The emerging epitranscriptome plays an essential role in female fertility. As the most prevalent internal mRNA modification, N6-methyladenine (m⁶A) methylation regulate mRNA fate and translational efficiency. However, whether m⁶A methylation was involved in the aging-related ovarian reserve decline has not been investigated. Herein, we performed m⁶A transcriptome-wide profiling in the ovarian granulosa cells of younger women (younger group) and older women (older group).

Results

m⁶A methylation distribution was highly conserved and enriched in the CDS and 3'UTR region. Besides, an increased number of m⁶A methylated genes were identified in the older group. Bioinformatics analysis indicated that m⁶A

SUBMITTER: Liu C 

PROVIDER: S-EPMC8961905 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature