Effects of different positive end-expiratory pressure titration strategies during prone positioning in patients with acute respiratory distress syndrome: a prospective interventional study.

ABSTRACT:

Background

Prone positioning in combination with the application of low tidal volume and adequate positive end-expiratory pressure (PEEP) improves survival in patients with moderate to severe acute respiratory distress syndrome (ARDS). However, the effects of PEEP on end-expiratory transpulmonary pressure (Ptp_exp) during prone positioning require clarification. For this purpose, the effects of three different PEEP titration strategies on Ptp_exp, respiratory mechanics, mechanical power, gas exchange, and hemodynamics were evaluated comparing supine and prone positioning.

Methods

In forty consecutive patients with moderate to severe ARDS protective ventilation with PEEP titrated according to three different titration strategies was evaluated during supine

SUBMITTER: Boesing C 

PROVIDER: S-EPMC8962042 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature