Ultrasmall iron oxide nanoparticles cause significant toxicity by specifically inducing acute oxidative stress to multiple organs.

ABSTRACT:

Background

Iron oxide nanoparticles have been approved by food and drug administration for clinical application as magnetic resonance imaging (MRI) and are considered to be a biocompatible material. Large iron oxide nanoparticles are usually used as transversal (T₂) contrast agents to exhibit dark contrast in MRI. In contrast, ultrasmall iron oxide nanoparticles (USPIONs) (several nanometers) showed remarkable advantage in longitudinal (T₁)-weighted MRI due to the brighten effect. The study of the toxicity mainly focuses on particles with size of tens to hundreds of nanometers, while little is known about the toxicity of USPIONs.

Results

We fabricated Fe₃O₄ nanoparticles with diameters of 2.3, 4.2, and 9.3 nm and evaluated their to

SUBMITTER: Wu L 

PROVIDER: S-EPMC8962100 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature