Potential Roles of Long Noncoding RNAs as Therapeutic Targets in Organ Transplantation.

ABSTRACT: Organ transplantation is the most preferred treatment option for end-stage organ diseases; however, allograft rejection is the major hurdle in successful long-term transplant survival. In spite of developing better HLA matching and more effective immunosuppressive regimen, one-year graft survival has been increased by nearly 90% and the incidence of acute rejection by one-year post-transplantation has been decreased by 12.2% in the last decades, chronic allograft rejection has remained as one of the major obstacles to the long-lasting survival of the transplanted allograft. Therefore, seemingly preventing the allograft rejection and inducing immunological tolerance against transplanted allografts is one of the primary goals in transplantation research to enable long-lasting graft survival.

SUBMITTER: Salehi S 

PROVIDER: S-EPMC8962195 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature