Biomimetic GBM-targeted drug delivery system boosting ferroptosis for immunotherapy of orthotopic drug-resistant GBM.

ABSTRACT:

Background

Clinical studies have shown that the efficacy of programmed cell death receptor-1/programmed cell death ligand-1 (PD-1/PD-L1) inhibitors on glioblastoma (GBM) is much lower than what is expected because of the low immunogenicity of GBM. Ferroptosis of cancer cells can induce the maturation of dendritic cells (DC cells) and increase the activity of T cell. The activated T cells release IFN-γ, which subsequently induces the ferroptosis of cancer cells. Thus, the aim of this paper is to set up a new GBM-targeted drug delivery system (Fe₃O₄-siPD-L1@M_-BV2) to boost ferroptosis for immunotherapy of drug-resistant GBM.

Results

Fe₃O₄-siPD-L1@M_-BV2 significantly increased the accumulation of siPD-L1 and Fe

SUBMITTER: Liu B 

PROVIDER: S-EPMC8962245 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature