The War Is on: The Immune System against Glioblastoma-How Can NK Cells Drive This Battle?

ABSTRACT: Natural killer (NK) cells are innate lymphocytes that play an important role in immunosurveillance, acting alongside other immune cells in the response against various types of malignant tumors and the prevention of metastasis. Since their discovery in the 1970s, they have been thoroughly studied for their capacity to kill neoplastic cells without the need for previous sensitization, executing rapid and robust cytotoxic activity, but also helper functions. In agreement with this, NK cells are being exploited in many ways to treat cancer. The broad arsenal of NK-based therapies includes adoptive transfer of in vitro expanded and activated cells, genetically engineered cells to contain chimeric antigen receptors (CAR-NKs), in vivo stimulation of NK cells (by cytokine therapy, checkpoint bloc

SUBMITTER: da Silva LHR 

PROVIDER: S-EPMC8962431 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature