NAP1L1 promotes tumor proliferation through HDGF/C-JUN signaling in ovarian cancer.

ABSTRACT:

Background

Nucleosome assembly protein 1-like 1 (NAP1L1) is highly expressed in various types of cancer and plays an important role in carcinogenesis, but its specific role in tumor development and progression remains largely unknown. In this study, we suggest the potential of NAP1L1 as a prognostic biomarker and therapeutic target for the treatment of ovarian cancer (OC).

Methods

In our study, a tissue microarray (TMA) slide containing specimens from 149 patients with OC and 11 normal ovarian tissues underwent immunohistochemistry (IHC) to analyze the correlation between NAP1L1 expression and clinicopathological features. Loss-of- function experiments were performed by transfecting siRNA and following lentiviral gene transduction into SKOV3 and OVCAR3 cells. Cell proliferat

SUBMITTER: Xiaohua Zhu 

PROVIDER: S-EPMC8962469 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature