Long-term impact of the metabolic status on weight loss-induced health benefits.

ABSTRACT:

Background

While short-term effects of weight loss on quality of life and metabolic aspects appear to be different in metabolically healthy (MHO) and metabolically unhealthy obese (MUO), respective long-term data is still missing. Given the high relevance of long-term changes, we aimed to address these in this post-hoc analysis of the MAINTAIN trial.

Methods

We analyzed 143 overweight/obese subjects (BMI ≥ 27 kg/m², age ≥ 18 years) before and after a 3-month weight loss program (≥ 8% weight loss), after a 12-month period of a randomized weight maintenance intervention (n = 121), and after another 6 months without intervention (n = 112). Subjects were retrospectively grouped into MHO and MUO by the presence of metabolic syndrome and secondarily by estimates of insu

SUBMITTER: Soll D 

PROVIDER: S-EPMC8962471 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature