Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation.

ABSTRACT: MCPIP1 (Regnase-1, encoded by the ZC3H12A gene) regulates the mRNA stability of several inflammatory cytokines. Due to the critical role of this RNA endonuclease in the suppression of inflammation, Mcpip1 deficiency in mice leads to the development of postnatal multiorgan inflammation and premature death. Here, we generated mice with conditional deletion of Mcpip1 in the epidermis (Mcpip1^EKO). Mcpip1 loss in keratinocytes resulted in the upregulated expression of transcripts encoding factors related to inflammation and keratinocyte differentiation, such as IL-36α/γ cytokines, S100a8/a9 antibacterial peptides, and Sprr2d/2h proteins. Upon aging, the Mcpip1^EKO mice showed impaired skin integrity that led to the progressive development of spontaneous skin pathology and s

SUBMITTER: Konieczny P 

PROVIDER: S-EPMC8962524 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature