Life-threatening anaphylaxis in children with cow's milk allergy during oral immunotherapy and after treatment failure.

ABSTRACT:

Background

Oral immunotherapy (OIT) is a promising therapeutic approach for children with persistent IgE-mediated cow's milk allergy (CMA) but data are still limited.

Objective

To analyze the prevalence of life-threatening anaphylaxis in children with persistent CMA undergoing OIT and to evaluate potential risk factors.

Methods

This is a retrospective cohort study among children with persistent CMA undergoing OIT over a 20-year period, following a specific Oral Tolerance Induction protocol. Adverse reactions during the whole period and data on long-term outcome were registered. Descriptive and nondescriptive statistics were used to describe data.

Results

Three hundred forty-two children were evaluated. During OIT, 12 children (3.5%) presented severe anaphylacti

SUBMITTER: Badina L 

PROVIDER: S-EPMC8962636 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature