Conflicting Roles of ZFP36L1 in Regulating the Progression of Muscle Invasive Bladder Cancer.

ABSTRACT: As the most common carcinoma of the human urinary system, bladder cancer (BC) is characterized by high recurrence, and poor prognosis after metastasis. In the past decade, genome-wide expression and sequencing studies had identified key genes and pathways related to BC, and pictured the comprehensive molecular features of the disease. Our previous study indicated that the coding gene of zinc finger protein 36 like 1 (ZFP36L1) mutated frequently in bladder tumor tissues and may be a potential suppressor for BC. The present study aimed to further investigate the role of ZFP36L1 in BC, and the survival analysis based on TCGA dataset revealed that high expressing level of ZFP36L1 associated with poorer prognosis of the patients with muscle invasive bladder cancer (MIBC). T

SUBMITTER: Yuan S 

PROVIDER: S-EPMC8962643 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature