Intraventricular Plus Systemic Antibiotic Therapy for Treating Polymyxin-Resistant Klebsiella pneumoniae Ventriculitis: A Case Report.

ABSTRACT:

Background

Treating central nervous system (CNS) infections caused by extensively drug-resistant (XDR) gram-negative bacilli, such as carbapenem-resistant Klebsiella pneumoniae, represents a significant clinical challenge. Polymyxin is occasionally used as a salvage treatment for this severe CNS infection. We report here a rare case of polymyxin-resistant Klebsiella pneumoniae ventriculitis, which was successfully treated with ventricular injections and intravenous antibiotics.

Methods

A 53-year-old male underwent a decompressive craniectomy and was referred to our hospital with cerebrospinal fluid incisional leakage and persistent fever.

Results

The minimum inhibitory concentration of polymyxin B in this patient increased from 2 to 4 μg/mL during the co

SUBMITTER: Wang H 

PROVIDER: S-EPMC8962704 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature