Short-term bioelectric stimulation of collective cell migration in tissues reprograms long-term supracellular dynamics.

ABSTRACT: The ability to program collective cell migration can allow us to control critical multicellular processes in development, regenerative medicine, and invasive disease. However, while various technologies exist to make individual cells migrate, translating these tools to control myriad, collectively interacting cells within a single tissue poses many challenges. For instance, do cells within the same tissue interpret a global migration 'command' differently based on where they are in the tissue? Similarly, since no stimulus is permanent, what are the long-term effects of transient commands on collective cell dynamics? We investigate these questions by bioelectrically programming large epithelial tissues to globally migrate 'rightward' via electrotaxis. Tissues clearly developed distinct rear

SUBMITTER: Wolf AE 

PROVIDER: S-EPMC8962779 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature