Mucus Plugs in Asthma at CT Associated with Regional Ventilation Defects at ³He MRI.

ABSTRACT: Background Airway mucus plugs in asthma are associated with exacerbation frequency, increased eosinophilia, and reduced lung function. The relationship between mucus plugs and spatially overlapping ventilation abnormalities observed at hyperpolarized gas MRI has not been assessed quantitatively. Purpose To assess regional associations between CT mucus plugs scored by individual bronchopulmonary segment and corresponding measurements of segmental ventilation defect percentage (VDP) at hyperpolarized helium 3 (³He) MRI. Materials and Methods In this secondary analysis of a Health Insurance Portability and Accountability Act-compliant prospective observational cohort, participants in the Severe Asthma Research Program (SARP) III (NCT01760915) between December 2012 and August 2015 u

SUBMITTER: Mummy DG 

PROVIDER: S-EPMC8962781 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature