Dataset Information
Somatic Mutations in TP53 Gene in Colombian Patients With Non-melanoma Skin Cancer.
Ontology highlight
ABSTRACT: Background/aim
Non-melanoma skin cancer is the most common cancer in the world. Somatic mutations in the TP53 gene are associated with the development of this cancer. To describe mutations in exons 5-8 of the TP53 gene in a sample of Colombian patients with non-melanoma skin cancer.Materials and methods
One hundred and fifteen patients with non-melanoma skin cancer were included. Exons 5-8 were amplified and analyzed by PCR-High Resolution Melting and Sanger sequencing.Results
Fifty-seven patients with basal cell carcinomas and 58 with squamous cell carcinomas were studied. 16% of patients with basal cell carcinoma and 26% of patients with squamous cell carcinoma had mutations in the TP53 gene. The most frequent mutations were substitutions, while three patients had deletions. The most frequent mutation was p.R158G.Conclusion
The analysis showed that Colombian individuals with non-melanoma skin cancer have genetic TP53 variants different from those reported as recurrent for this disease.
SUBMITTER: Dary Gutierrez-Castaneda L
PROVIDER: S-EPMC8962838 | biostudies-literature | 2022 Jan-Feb
REPOSITORIES: biostudies-literature
Publications
Somatic Mutations in TP53 Gene in Colombian Patients With Non-melanoma Skin Cancer.
Cancer diagnosis & prognosis 20220103 1
<h4>Background/aim</h4>Non-melanoma skin cancer is the most common cancer in the world. Somatic mutations in the TP53 gene are associated with the development of this cancer. To describe mutations in exons 5-8 of the TP53 gene in a sample of Colombian patients with non-melanoma skin cancer.<h4>Materials and methods</h4>One hundred and fifteen patients with non-melanoma skin cancer were included. Exons 5-8 were amplified and analyzed by PCR-High Resolution Melting and Sanger sequencing.<h4>Result ...[more]